Product Description

TPOR (phospho-Tyr626) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35465-50, RA35465-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MPL proto-oncogene, thrombopoietin receptor (MPL) Homo sapiens In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)

Clonality: Polyclonal

Dilution: WB 1:1000-2000

Molecular Weight: 69, 40

Protein Molecular Weight (kDa): 69, 40

Storage: -20°C/1 year

Human Gene ID: 4352

Human SwissProt Number: P40238

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only