TR4 Polyclonal Antibody-GCP112

TR4 Polyclonal Antibody

Catalogue Numbers: GCP112-50, GCP112-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: P49116

Host: Rabbit

Reactivity: Human,Pig

Applications: WB

All Applications: WB: 1:2000~1:5000

Background: Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2. TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs). TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation. TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation. High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2. Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TR4 polyclonal antibody detects endogenous levels of TR4 protein.

Extra Notes: Western blot (WB) analysis of TR4 polyclonal antibody at 1:2000 dilution
Lane1:The Lung tissue lysate of Pig(40ug)
Lane2:The Spleen tissue lysate of Pig(40ug)
Lane3:The Brain tissue lysate of Pig(40ug)
Lane4:HEK293T whole cell lysate(40ug)
Lane5:Hela whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 67 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4; NR2C2; TAK1, TR4

Immunogen: Synthetic peptide, corresponding to Human TR4.

Conjugate: Unconjugated

Modification: Unmodified