TRAF2 (Phospho-Ser11) Rabbit Polyclonal Antibody - BT-AP05238

TRAF2 (Phospho-Ser11) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP05238-20, BT-AP05238-50, BT-AP05238-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with| and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors| and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD| a TNF receptor associated apoptotic signal transducer| ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1| an apoptosis inhibitor possessing ubiquitin ligase activity| can unbiquitinate and induce the degradation of this pro

Research Areas: Signal transduction; Cancer; Cardiovascular; Cell biology

Target Protein: TRAF2

Applications: WB

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: TRAF2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q12933; Mouse: P39429

Synonyms: TRAF2;Ser11; TNF receptor-associated factor 2; EC 6.3.2.-; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3

GeneID: Human: 7186; Mouse: 22030

Research Use Only