Product Description

Transcriptional Enhancer Factor TEF Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11684-50, MB11684-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q15561

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TEAD1/TEAD2/TEAD3/TEAD4 in K562, HelaLysates using Transcriptional Enhancer Factor TEF antibody.

Bioworld Molecular Weight: Calculated MW: 48 kDa; Observed MW: 54 kDa

Specificity: IgG

Alternative Name: DTEF 1; NTEF 1; TCF13; TEAD1; TEAD2; TEAD3; TEAD4; TEAD5; TEF1; TEF4; TEF5

Immunogen: Recombinant protein of human TEAD4

Conjugate: Unconjugated

Modification: Unmodified