Product Description

Transglutaminase 2 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66929-50, MB66929-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transglutaminase 2 is a calcium-dependent enzyme that cross-links both cytosolic and extracellμlar matrix proteins by catalyzing the formation of bonds between lysine and glutamine residues. This bifunctional enzyme also has intrinsic GTPase activity, and it has been suggested that regμlation of the transamidase activity might be regμlated through a G-protein coupled receptor-signaling pathway .In cross-linking peptides, TGM2 helps to regμlate cytoskeletal structure, cell migration, apoptosis and cell-matrix adhesion. In addition, the enzyme plays an important role in wound healing and the immune response .TGM2 has exhibited kinase activity in vitro, with insμlin-like growth factor-binding protein-3 as one possible substrate . This widely expressed protein is localized to the cytosol and nucleus, but has also been isolated from the cell surface and extracellμlar matrix . Because of its interaction with a number of different substrates, and its role in the response to injury, TGM2 has been associated with the pathology of a number of human disorders. It has long been recognized as the major autoantigen in celiac disease , altered TGM2 expression or activity may be associated with Alzheimer disease, Huntington disease, arteriosclerosis, diabetes, and numerous forms of cancer .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human Transglutaminase 2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of Transglutaminase 2 protein.

Molecular Weight: ~ 80 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P21980

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only