TRF1 (phospho Ser219) rabbit pAb - ES7369

TRF1 (phospho Ser219) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7369-50, ES7369-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008],

Alternate Name: TERF1; PIN2; TRBF1; TRF; TRF1; Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human Telomeric Repeat Binding Factor 1 around the phosphorylation site of Ser219. AA range:185-234

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 55kD

Human Gene ID: 7013

Human SWISS Prot NO: P54274

Subcellular Location: Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.

Research Use Only