TRIB2 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A11661-20, A11661-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 39kDa
Observed Molecular Weight: 49kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 28951
SWISS: Q92519
Alternate Names: C5FW; TRB2; GS3955; TRIB2
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Signal Transduction, Kinase, Serine threonine kinases, Immunology Inflammation, Stem Cells, Hematopoietic Progenitors, Cardiovascular.
NCBI Alias: TRIB2
Research Use Only