TRIF rabbit pAb - ES8501

TRIF rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8501-50, ES8501-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012],

Alternate Name: TIR domain-containing adapter molecule 1 (TICAM-1; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; TIR domain-containing adapter protein inducing IFN-beta)

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from TRIF at AA range: 663-712

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 80kD

Human Gene ID: 148022

Human SWISS Prot NO: Q8IUC6

Subcellular Location: Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Mitochondrion. Colocalizes with UBQLN1 in the autophagosome (PubMed:21695056). Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly (I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly (I:C) RNA ligand stimulation (By similarity).

Research Use Only