TRIM23 Monoclonal Antibody-MB11721

TRIM23 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11721-50, MB11721-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P36406

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TRIM23 in K562, C6, 3T3, HelaLysates using TRIM23 antibody.

Bioworld Molecular Weight: Calculated MW: 64 kDa; Observed MW: 64 kDa

Specificity: IgG

Alternative Name: ARD1; ARFD1; RNF46

Immunogen: A synthetic peptide of human TRIM23

Conjugate: Unconjugated

Modification: Unmodified