TRIM25 Monoclonal Antibody-MB11723

TRIM25 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11723-50, MB11723-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q14258

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background: Functions as an ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 71 kDa; Observed MW: 71 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TRIM25/EFP in K562, rat Brain, C6, Hela lysates using TRIM25 antibody., Immunocytochemistry analysis of TRIM25/EFP in MCF-7 using TRIM25/EFP antibody, and DAPI

Alternative Name: TRIM25; EFP; RNF147; ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147

Immunogen: A synthetic peptide of human TRIM25

Conjugate: Unconjugated

Modification: Unmodified