Product Description

TRIM56 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11724-50, MB11724-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q9BRZ2

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 81 kDa; Observed MW: 81 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TRIM56 in Hela lysates using TRIM56 antibody., Immunocytochemistry analysis of TRIM56 in Hela using TRIM56 antibody, and DAPI

Alternative Name: RING finger protein 109; RNF109

Immunogen: A synthetic peptide of human TRIM56

Conjugate: Unconjugated

Modification: Unmodified