TRIPC Polyclonal Antibody - BT-AP15153

TRIPC Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15153-20, BT-AP15153-50, BT-AP15153-100

Citations, Manuals and MSDS Available upon request.

Background: Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the UPL family. K-HECT subfamily.,Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,Contains 1 WWE domain.,subunit:PA700 is composed of at least 16 distinct peptides ranging from 20-112 kDa.,

Research Areas: Epigenetics and nuclear signaling

Target Protein: TRIP12

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: E3 ubiquitin-protein ligase TRIP12

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q14669; Mouse: G5E870; Rat: F1LP64

Synonyms: E3 ubiquitin-protein ligase TRIP12;EC 6.3.2.-;E3 ubiquitin-protein ligase for Arf;ULF;Thyroid receptor-interacting protein 12;TR-interacting protein 12;TRIP-12

GeneID: Human: 9320

Research Use Only