TROP2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91376-50, BS91376-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P09758(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, ICC IHC
All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
Background: TROP-2, also known as tumor-associated calcium signal transducer 2 (TACSTD2), pancreatic carcinoma marker protein GA733-1, membrane component chromosome 1, surface marker 1 (M1S1) or epithelial glycoprotein-1 (EGP-1), is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thryoglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. TROP-2 plays a role in tranducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multistratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells. Mutations in the gene encoding TROP-2 can result in gelatinous drop-like corneal dystrophy (GDLD) also referred to as lattice corneal dystrophy type III, an autosomal recessive disorder that causes severe visual impairment.
Purification and Purity: Protein affinity purified.
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: TROP2 polyclonal antibody detects endogenous levels of TROP2 protein.
Bioworld Molecular Weight: 35 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of TROP2 on A431 cell lysate using anti-TROP2 antibody at 1/500 dilution., ICC staining TROP2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: TACSTD2, GA733-1, M1S1, TROP2, Cell surface glycoprotein Trop 2, Cell surface glycoprotein Trop-2, Cell surface glycoprotein Trop2, Epithelial glycoprotein 1, GA733 1, GA7331, M1S 1, M1S1, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733 1, Pancreatic carcinoma marker protein GA733-1, Pancreatic carcinoma marker protein GA7331, TACD 2, TACD2, TACSTD 2, Tacstd2, Trop 2, Trop2, Tumor associated calcium signal transducer 2 precursor, Tumor-associated calcium signal transducer 2,
Immunogen: Recombinant protein.
Conjugate: Unconjugated
Modification: Unmodified