Product Description

Tropomyosin α (E40) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2897-50, BS2897-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind Actin filaments and function to modμlate Actin-Myosin interaction and stabilize Actin filament structure. α-Tropomyosin is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. β-Tropomyosin is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with Actin filaments may increase the rigidity of Actin filaments. Tropomyosin also interacts with Caldesmon to regμlate smooth muscle contraction.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: AA986836, AI854628, Alpha tropomyosin, alpha-TM, Alpha-tropomyosin, C15orf13, cardiomyopathy, hypertrophic 3, CMD1Y, CMH3, HTM alpha, OTTHUMP00000163688, sarcomeric tropomyosin kappa, TM2, Tmpa, TMSA, Tpm-1, TPM1, TPM1, Tropomyosin 1, Tropomyosin alpha 1 chain, Tropomyosin alpha-1 chain, Tropomyosin-1,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 1-50 of Human Tropomyosin α.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Tropomyosin α (E40) polyclonal antibody detects endogenous levels of Tropomyosin α protein.

Molecular Weight: ~ 32 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P09493

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only