Tropomyosin 1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91377-50, BS91377-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P09493(Human) P58771(Mouse) P04692(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC FC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Background: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind Actin filaments and function to modulate Actin-Myosin interaction and stabilize Actin filament structure. Tropomyosin α is encoded by the TPM1 gene, which maps to human chromosome 15q22.1 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin β is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with Actin filaments may increase the rigidity of Actin filaments. Tropomyosin also interacts with Caldesmon to regulate smooth muscle contraction.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Specificity: Tropomyosin 1 polyclonal antibody detects endogenous levels of Tropomyosin 1 protein.
Bioworld Molecular Weight: 33 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Tropomyosin 1 on rat heart tissue using anti-Tropomyosin 1 antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat smooth muscle tissue using anti-Tropomyosin 1 antibody. Counter stained with hematoxylin.
Alternative Name: TPM1, C15orf13, TMSA, AA986836, AI854628, Alpha tropomyosin, alpha-TM, Alpha-tropomyosin, C15orf13, cardiomyopathy, hypertrophic 3, CMD1Y, CMH3, HTM alpha, HTM-alpha, OTTHUMP00000163688, sarcomeric tropomyosin kappa, TM2, Tmpa, TMSA, Tpm-1, TPM1, TPM1, tropomyosin 1 (alpha), tropomyosin 1 (alpha) isoform 1, tropomyosin 1 (alpha) isoform 2, tropomyosin 1 (alpha) isoform 3, tropomyosin 1 (alpha) isoform 4, tropomyosin 1 (alpha) isoform 5, tropomyosin 1 (alpha) isoform 6, tropomyosin 1 (alpha) isoform 7, Tropomyosin 1, Tropomyosin alpha 1 chain, Tropomyosin alpha-1 chain, Tropomyosin, skeletal muscle alpha, Tropomyosin-1,
Immunogen: Recombinant protein within human Tropomyosin 1 aa 100-300.
Conjugate: Unconjugated
Modification: Unmodified