Troponin I-C Monoclonal Antibody - BT-MCA1235

Troponin I-C Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA1235-50, BT-MCA1235-100

Citations, Manuals and MSDS Available upon request.

Background: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit| blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Research Areas: Signal transduction; Stem cells; Cardiovascular; Developmental biology

Target Protein: TNNI3

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Troponin I cardiac muscle

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P19429; Mouse: P48787

Synonyms: TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I

GeneID: Human: 7137

Research Use Only