Product Description

TRP12/TRPV4 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS65952-50, BS65952-100

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Swiss-Prot: Q9HBA0

Host: Rabbit

Reactivity: Human, Mouse, Rat,Chicken,Dog, Pig, Cow,

Applications: FCM

All Applications: Flow-Cyt=1ug/test

Background: The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke appropriate protective reflexes. TRPV4 is a non selective calcium permeant, swell activated, cation channel probably involved in osmotic and mechano sensitivity. Activation by exposure to hypotonicity within the physiological range, low pH, citrate and phorbol esters exhibits an outward rectification. Once activated the channel seems to be regulated in a calmodulin dependent manner, with a negative feedback mechanism.

Purification and Purity: affinity purified by Protein A

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TRP12/TRPV4 Polyclonal Antibody detects endogenous levels of TRP12/TRPV4 protein.

Bioworld Molecular Weight: 96kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: osm-9-like TRP channel 4; OTRPC 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; Transient receptor potential protein 12; TRP 12; TRP12; TRPV 4; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR 4; VR OAC; VR4; VRL 2; VRL2; VROAC.

Immunogen: KLH conjugated synthetic peptide derived from human TRPV4:301-400/871

Conjugate: Unconjugated

Modification: Unmodified