Product Description

TRPC6 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS71105-50, BS71105-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y210

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-P

All Applications: WB: 1:500-1:1000
IHC-P: 1:50-1:200

Background: The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TRPC6 polyclonal antibody detects endogenous levels of TRPC6 protein.

Bioworld Molecular Weight: ~ 106 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of Mouse pancreas, using TRPC6 antibody at 1:1000 dilution., Western blot analysis of extracts of Rat brain, using TRPC6 antibody at 1:1000 dilution., Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using TRPC6 pAb at dilution of 1:100 (40x lens)., Immunohistochemistry analysis of paraffin-embedded mouse kidney using TRPC6 pAb at dilution of 1:100 (40x lens).

Alternative Name: TRP6; FSGS2

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-600 of human TRPC6 (NP_004612.2).

Conjugate: Unconjugated

Modification: Unmodified