Tsg 101 Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP09259-20, BT-AP09259-50, BT-AP09259-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by TSG101 (tumor susceptibility 101) belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in TSG101 occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Research Areas: Cell Biology
Target Protein: TSG101
Applications: WB, IHC-p, IF, ELISA
Reactivity: Human, Mouse, Rat, Monkey
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: Tsg 101 Antibody
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Molecular Weight (Da): 43944
UniProt Accession: Human: Q99816; Mouse: Q61187; Rat: Q6IRE4
Synonyms: TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
GeneID: Human: 7251; Mouse: 22088; Rat: 292925
Research Use Only