Product Description

TSG101 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67185-50, MB67185-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Tumor susceptibility gene 101 protein (TSG101) is a mμlti-domain cytoplasmic protein and fundamental component of ESCRT complex I, which is intimately involved in regμlating the trafficking of proteins throughout the endosomal compartment. In addition to regμlating the sorting of ubiquitinated cargo proteins within the endosomal compartment, TSG101 is involved in regμlating diverse biological processes, such as cell proliferation, viral budding and release, and exosome biosynthesis. While it is clear that TSG101 expression levels are tightly controlled and complete loss of expression causes embryonic lethality due to cell cycle arrest and cell death, the role of TSG101 in malignancy has yet to be fμlly elucidated. Indeed, TSG101 was initially dubbed a tumor suppressor but there are mμltiple studies that demonstrate an elevated expression in human cancers.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human TSG101. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of TSG101 protein.

Molecular Weight: ~ 50 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q99816

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only