Product Description

TSPO/PBR Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65639-50, BS65639-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is specμlated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Rabbit

Applications: IHC-P

Alternate Names: BPBS, BZRP, DBI, IBP, Isoquinoline carboxamide-binding protein, MBR, mDRC, Mitochondrial benzodiazepine receptor, PBR, PBS, Peripheral benzodiazepine receptor, Peripheral benzodiazepine receptor-related protein, Peripheral type benzodiazepine receptor, pk18, PKBS, PTBR, Ptbzr, PTBZR02, RATPTBZR02, translocator protein (18kDa), Translocator protein, TSPO, Tspo1, Benzodiazapine receptor (peripheral), Benzodiazepine peripheral binding site.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human PBR

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: TSPO/PBR Polyclonal Antibody detects endogenous levels of TSPO/PBR protein.

Molecular Weight: 18kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: B1AH88

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only