Product Description

TTC11 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91382-50, BS91382-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y3D6(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC IF, IHC

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Fis1 localizes to the outer mitochondrial membrane and, along with dynamin-related protein (Drp1), participates in mitochondrial fission. Fission and fusion mechanisms regulate mitochondrial morphology within the cell. Fission frequency is determined by the level of Fis1 molecules at the mitochondrial surface. Fis1 contains a C-terminal domain, which is required for mitochondrial localization, and an N-terminal domain, which is necessary for mitochondrial fission. Fragmentation of the mitochondrial network by Fis1 leads to cytochrome c release and apoptosis. The mitochondrial fission mechanisms may be involved in positively and negatively regulating apoptosis.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: TTC11 polyclonal antibody detects endogenous levels of TTC11 protein.

Bioworld Molecular Weight: 17 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TTC11 on SK-Br-3 cell using anti-TTC11 antibody at 1/2,000 dilution., ICC staining TTC11 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: hFis1, TPR repeat protein 11, FIS1, TTC11, 2010003O14Rik, CGI 135, CGI135, FIS 1, FIS1, Fis1 homolog, FIS1, S. cerevisiae, homolog of, FIS1, Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae), Fission 1 (mitochondrial outer membrane) homolog (yeast), Fission 1 (mitochondrial outer membrane) homolog, Fission 1 homolog, H NH0132A01.6, hFis 1, hFis1, Mitochondrial fission 1 protein, mitochondrial fission molecule, Tetratricopeptide repeat domain 11, Tetratricopeptide repeat protein 11, TPR repeat protein 11, TTC 11,

Conjugate: Unconjugated

Modification: Unmodified