TTR mouse Monoclonal Antibody (3B5) - BT-MCA1243

TTR mouse Monoclonal Antibody (3B5)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA1243-20, BT-MCA1243-50, BT-MCA1243-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein| it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported| most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Research Areas: Neuroscience; Cardiovascular

Target Protein: TTR

Applications: WB, IHC-p, IF

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Transthyretin

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P02766; Mouse: P07309

Synonyms: Transthyretin; ATTR; Prealbumin; TBPA

GeneID: Human: 7276

Research Use Only