Tuberin Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91384-50, BS91384-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P49815(Human) Q61037(Mouse) P49816(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC FC
All Applications: WB:1:1,000-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Tuberin polyclonal antibody detects endogenous levels of Tuberin protein.
Bioworld Molecular Weight: 200 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Tuberin on Jurkat cell lysates using anti-Tuberin antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-Tuberin antibody. Counter stained with hematoxylin.
Alternative Name: TSC2, TSC4, FLJ43106, LAM, OTTHUMP00000158940, OTTHUMP00000198394, OTTHUMP00000198395, PPP1R160, Protein phosphatase 1, regulatory subunit 160, tsc2, TSC2, TSC4, TSC4 gene, formerly, TSC4, formerly, Tuberin, Tuberous sclerosis 2, Tuberous sclerosis 2 protein, Tuberous sclerosis 2 protein homolog,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified