Product Description

TUBGCP4 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-52657-60, E-AB-52657-120, E-AB-52657-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: TUBGCP4

Target Synonym: 76P; FLJ14797; Gamma tubulin complex component 4; Gamma tubulin ring complex protein (76p gene); Gamma tubulin ring complex protein; Gamma-ring complex protein 76 kDa; GCP 4; GCP4; Grip76; h76p; hGCP4; Hgrip76; TUBGCP 4; TUBGCP4; Tubulin gamma complex associated protein 4

Research Areas: Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9UGJ1

Background: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.TUBGCP4 (Tubulin Gamma Complex Associated Protein 4) is a Protein Coding gene. Diseases associated with TUBGCP4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 3 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP6.

Concentration: 0.66 mg/mL

Immunogen: Fusion protein of human TUBGCP4

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Calculated MW: 76 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only