TXNRD1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91390-50, BS91390-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q16881(Human) Q9JMH6(Mouse) O89049(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC, IHC, IP, FC
All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx reductases (TrxR1 and TrxR2) are ubiquitous Ly noble flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val- Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: TXNRD1 polyclonal antibody detects endogenous levels of TXNRD1 protein.
Bioworld Molecular Weight: 55 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of TXNRD1 on Hela (1) and human liver tissue lysate (2) using anti-TXNRD1 antibody at 1/1,000 dilution., ICC staining TXNRD1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: TR, GRIM-12, TXNRD1, GRIM12, KDRF, cytoplasmic, Gene associated with retinoic and IFN-induced mortality 12 protein, Gene associated with retinoic and interferon-induced mortality 12 protein, Gene associated with retinoid IFN induced mortality 12 protein, GRIM 12, GRIM-12, GRIM12, KDRF, KM 102 derived reductase like factor, KM-102-derived reductase-like factor, MGC9145, Oxidoreductase, Thioredoxin reductase 1, Thioredoxin reductase 1 cytoplasmic, Thioredoxin reductase GRIM 12, Thioredoxin reductase TR1, TR 1, TR, TR1, TRXR 1, TRXR1, TRXR1, TXNR, TXNRD 1, Txnrd1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified