TXNRD2 Monoclonal Antibody-MB66540

TXNRD2 Monoclonal Antibody

Catalogue Numbers: MB66540-50, MB66540-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q9NNW7

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Thioredoxin reductases are selenoproteins that are critical for maintaining cellular redox balance and eliminating reactive oxygen species (ROS). There are three known mammalian thioredoxin reductases: TRXR1/TXNRD1 (cytosolic), TRXR2/TXNRD2 (mitochondrial), and TRXR3/TXNRD3 (testis-specific). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation. TRXR2 is critical for normal heart development and function. TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice results in congestive heart failure. In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy. A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of TXNRD2 protein.

Extra Notes: Western blot analysis of TXNRD2 expression in A431 (A), U251 (B), U2OS (C), Lncap (D), Hela (E) whole cell lysates.

Bioworld Molecular Weight: ~ 56 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: KIAA1652; TRXR2; Thioredoxin reductase 2 mitochondrial; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3

Immunogen: Purified recombinant human TXNRD2 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified