Product Description

TXNRD2 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66540-50, MB66540-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Thioredoxin reductases are selenoproteins that are critical for maintaining cellμlar redox balance and eliminating reactive oxygen species (ROS). There are three known mammalian thioredoxin reductases: TRXR1/TXNRD1 (cytosolic), TRXR2/TXNRD2 (mitochondrial), and TRXR3/TXNRD3 (testis-specific). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation. TRXR2 is critical for normal heart development and function. TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice resμlts in congestive heart failure. In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy. A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: KIAA1652, TRXR2, Thioredoxin reductase 2 mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin reductase TR3

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant human TXNRD2 protein fragments expressed in E.coli.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of TXNRD2 protein.

Molecular Weight: ~ 56 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NNW7

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only