Product Description

Tyk 2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3976-50, BS3976-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regμlates cell growth, development, cell migration, innate and adaptive immunity.Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling.Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6.The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2.In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members.In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regμlate cytokine/growth factor responsive genes.Negatively regμlates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IP

Alternate Names: Non-receptor tyrosine-protein kinase TYK2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to Human Tyk 2.

Dilution: WB: 1:1000~1:2000
IP: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Tyk 2 polyclonal antibody detects endogenous levels of Tyk 2 protein.

Molecular Weight: ~ 134 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P29597

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only