Tyk 2 rabbit pAb - ES3658

Tyk 2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3658-50, ES3658-100

Citations, Manuals and MSDS Available upon request.

Background: tyrosine kinase 2 (TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],

Alternate Name: TYK2; Non-receptor tyrosine-protein kinase TYK2

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human TYK2. AA range:1020-1069

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 134kD

Human Gene ID: 7297

Human SWISS Prot NO: P29597

Subcellular Location: nucleus, cytoplasm, cytosol, cytoskeleton, membrane, extrinsic component of cytoplasmic side of plasma membrane, extracellular exosome,

Research Use Only