TYK2 (V1048) Polyclonal Antibody-BS3713

TYK2 (V1048) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3713-50, BS3713-100

Sizes: 50µl, 100µl

Swiss-Prot: P29597

Host: Rabbit

Reactivity: Human, Rat, Mouse

Applications: WB IF

Background: Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Tyk 2 (V1048) polyclonal antibody detects endogenous levels of Tyk 2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TYK2 (V1048) polyclonal antibody at 1:500 dilution
Lane 1: PC3 whole cell lysate (40ug)
Lane 2: HEK293T whole cell lysate (40ug)
Lane 3: A549 whole cell lysate (40ug)
Lane 4: MCF-7 whole cell lysate (40ug)
Lane 5: PC12 whole cell lysate (40ug), Immunofluorescence analysis of PC3 cells using TYK2 (V1048) antibody at dilution of 1:50.

Bioworld Molecular Weight: ~ 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Non-receptor tyrosine-protein kinase TYK2

Immunogen: Synthetic peptide, corresponding to Human TYK2.

Conjugate: Unconjugated

Modification: Unmodified