Product Description

TYR Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91393-50, BS91393-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P14679(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF, IHC

All Applications: WB:1:500-1:1,000
ICC:1:100-1:500
IHC:1:50-1:200

Background: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Defects in TYR are the cause of albinism oculocutaneous type 1B (OCA1B) [MIM:606952]; also known as albinism yellow mutant type. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TYR polyclonal antibody detects endogenous levels of TYR protein.

Bioworld Molecular Weight: 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining Tyrosinase in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining Tyrosinase in B16F1 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: TYR, ATN, CMM8, LB24 AB, LB24-AB, Monophenol monooxygenase, OCA1, OCA1A, OCAIA, Oculocutaneous albinism IA, SHEP3, SK29 AB, SK29-AB, Tumor rejection antigen AB, TYR, TYRO, tyrosinase (oculocutaneous albinism IA), Tyrosinase,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified