Product Description

UBASH3A Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5968-50, BS5968-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TμlA (T cell ubiquitin ligand), also known as UBASH3A (ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TμlA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumμlation of activated receptors on the cell surface. Additionally, TμlA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TμlA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Mμltiple isoforms of TμlA are produced due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC

Alternate Names: Ubiquitin-associated and SH3 domain-containing protein A, Cbl-interacting protein 4, CLIP4, Suppressor of T-cell receptor signaling 2, STS-2, T-cell ubiquitin ligand 1, TμlA-1, TμlA1, STS2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 356-401 of Human UBASH3A.

Dilution: WB: 1:500~1:1000
ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: UBASH3A polyclonal antibody detects endogenous levels of UBASH3A protein.

Molecular Weight: ~ 74 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P57075

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only