UBP18 rabbit pAb - ES12447

UBP18 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES12447-50, ES12447-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human UBP18 AA range: 66-116

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 11274

Human SWISS Prot NO: Q9UMW8

Subcellular Location: [Isoform 1]: Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm.

Research Use Only