UBP20 Rabbit Polyclonal Antibody - RA35832

UBP20 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35832-50, RA35832-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF) -1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2) . This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1：500-2000

Applications: WB

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 10868

SWISS: Q9Y2K6

Source: Rabbit

Research Use Only