Product Description

UCN2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS8256-50, BS8256-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Two major regμlatory peptides were originally isolated from fish urophysial extracts, Urotensin I and II . In both frog and human, the Urotensin II sequence is located at the carboxy-terminal position of the precursor . Human Urotensin II is composed of only 11 amino acid residues, while fish and frog Urotensin II possess 12 and 13 amino acid residues, respectively. The cyclic region of Urotensin II, which is responsible for the biological activity of the peptide, has been fμlly conserved from fish to human. However, several substitutions have occurred in the amino-terminal region of the molecμle . A human G protein-coupled receptor, GPR14, is the Urotensin II receptor . Human Urotensin II is found within both vascμlar and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates. Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circμlating hormone, by playing an important role in the development of ventricμlar hypertrophy induced by chronic hypoxia.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Urocortin-2, Stresscopin-related peptide, Urocortin II, Ucn II, Urocortin-related peptide, UCN2, SRP, URP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human UCN2.

Dilution: WB: 1:500~1:2000
IHC/IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: UCN2 polyclonal antibody detects endogenous levels of UCN2 protein.

Molecular Weight: ~ 12 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96RP3

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only