UCN2 Polyclonal Antibody-BS8256

UCN2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS8256-50, BS8256-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96RP3

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB: 1:500~1:2000
IHC/IF: 1:50~1:200

Background: Two major regulatory peptides were originally isolated from fish urophysial extracts, Urotensin I and II . In both frog and human, the Urotensin II sequence is located at the carboxy-terminal position of the precursor . Human Urotensin II is composed of only 11 amino acid residues, while fish and frog Urotensin II possess 12 and 13 amino acid residues, respectively. The cyclic region of Urotensin II, which is responsible for the biological activity of the peptide, has been fully conserved from fish to human. However, several substitutions have occurred in the amino-terminal region of the molecule . A human G protein-coupled receptor, GPR14, is the Urotensin II receptor . Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates. Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: UCN2 polyclonal antibody detects endogenous levels of UCN2 protein.

Bioworld Molecular Weight: ~ 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of rat skin cells, using UCN2 antibody., Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody at dilution of 1:100 (40x lens)., Immunofluorescence analysis of U2OS cell using UCN2 antibody. Blue: DAPI for nuclear staining.

Alternative Name: Urocortin-2; Stresscopin-related peptide; Urocortin II; Ucn II; Urocortin-related peptide; UCN2; SRP; URP

Immunogen: Recombinant full length Human UCN2.

Conjugate: Unconjugated

Modification: Unmodified