UCP3 Polyclonal Antibody - E-AB-67010

UCP3 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-67010-60, E-AB-67010-120, E-AB-67010-200 Citations, Manuals and MSDS Available upon request. Abbreviation: UCP3 Target Synonym: UCP3; SLC25A9 Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signaling transduction Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: IF Isotype: IgG Clonality: Polyclonal UNIProt ID: P55916 Background: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene. Concentration: 1mg/mL Immunogen: Recombinant protein of human UCP3. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: IF 1:50-1:200 Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only