UGT8 Polyclonal Antibody
Catalogue Numbers: BS60393-50, BS60393-100
Sizes: 50µl, 100µl
Alternative Name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase; CGT; UGT4
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q16880
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: UGT8 polyclonal antibody detects endogenous levels of UGT8 protein.
Bioworld Molecular Weight: ~ 61 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of UGT8 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: Raw264.7 cell lysate
Lane 3: sp2/0 cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human UGT8.
Conjugate: Unconjugated
Modification: Unmodified