UHRF1 Monoclonal Antibody - RA10650

UHRF1 Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10650-50, RA10650-100

Citations, Manuals and MSDS Available upon request.

Background: ubiquitin like with PHD and ring finger domains 1 (UHRF1) Homo sapiens This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014],

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB; IF/ICC

Species Cross-Reactivity: Human

GeneID (Human): 29128

SWISS: Q96T88

Source: Mouse

Research Use Only