UN13B rabbit pAb - ES12423

UN13B rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES12423-50, ES12423-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human UN13B AA range: 1325-1375

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 10497

Human SWISS Prot NO: O14795

Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).

Research Use Only