UNC45B Polyclonal Antibody - E-AB-52442

UNC45B Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-52442-60, E-AB-52442-120, E-AB-52442-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: UNC45B

Target Synonym: Cardiomyopathy associated 4 ; CMYA4 ; FLJ38610; MGC119540; MGC119541; OTTHUMP00000163855; Protein unc 45 homolog B; Protein unc-45 homolog B; SMUNC45; Striated muscle UNC45; UN45B; Unc 45 homolog B (C. elegans); Unc 45 homolog B; UNC 45B; UNC-45B; UNC45 ; UNC45B

Research Areas: Developmental biology, Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q8IWX7

Background: This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

Concentration: 0.9 mg/mL

Immunogen: Fusion protein of human UNC45B

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Calculated MW: 104/95 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only