Product Description

uPA (L239) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3454-50, BS3454-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The human urokinase-type plasminogen activator receptor (uPAR) is a 55-65 kDa, highly glycosylated, GPI-anchored cell surface receptor (the deglycosylated protein is 35 kDa). It is a central player in the plasminogen activation pathway. uPAR binds with high affinity to a serine protease urokinase-type plasminogen activator (uPA) and converts plasminogen to its active form plasmin in a spatially restricted manner on the cell surface. Plasmin further carries out the activation of uPA, which is inhibited by serpins, such as plasminogen activator inhibitors. Therefore, uPAR plays a key role in regμlating extracellμlar proteolysis. In addition, uPAR plays an important role in regμlating cell proliferation, adhesion, and mobility. Research studies have shown that overexpression of uPAR is found in various cancer cells and tissues.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Urokinase-type plasminogen activator, U-plasminogen activator, Upa, PLAU

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 211-260 of Human uPA.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: uPA (L239) polyclonal antibody detects endogenous levels of uPA protein.

Molecular Weight: ~ 48 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00749

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only