Product Description

USP11 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67014-50, MB67014-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains .Inhibits the degradation of target proteins by the proteasome . Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro).Plays a role in the regμlation of pathways leading to NF-kappa-B activation.Plays a role in the regμlation of DNA repair after double-stranded DNA breaks .Acts as a chromatin regμlator via its association with the Polycomb group (PcG) mμltiprotein PRC1-like complex, may act by deubiquitinating components of the PRC1-like complex .Promotes cell proliferation by deubiquitinating phosphorylated E2F1 .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, FC

Alternate Names: UHX1, Ubiquitin carboxyl-terminal hydrolase 11, Deubiquitinating enzyme 11, Ubiquitin thioesterase 11, Ubiquitin-specific-processing protease 11

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human USP11. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), FC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of USP11 protein.

Molecular Weight: ~ 115 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P51784

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only