Product Description

USP11 Monoclonal Antibody

Catalogue Numbers: MB67014-50, MB67014-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P51784

Host: Mouse

Reactivity: Human

Applications: WB, FC

All Applications: WB (1/500 - 1/1000), FC (1/10 - 1/50)

Background: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains .Inhibits the degradation of target proteins by the proteasome .
Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro).Plays a role in the regulation of pathways leading to NF-kappa-B activation.Plays a role in the regulation of DNA repair after double-stranded DNA breaks .Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex .Promotes cell proliferation by deubiquitinating phosphorylated E2F1 .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of USP11 protein.

Extra Notes: Western blot analysis of USP11 expression in Jurkat (A), Hela (B), LNCaP (C) whole cell lysates.

Bioworld Molecular Weight: ~ 115 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: UHX1; Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human USP11. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified