Product Description

USP15 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61734-50, BS61734-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecμles to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellμlar processes such as signal transduction, transcriptional activation and cell cycle progression. USP15 (ubiquitin specific peptidase 15), also known as UNPH4, is a member of the peptidase C19 family of proteins. Expressed in kidney, liver, placenta, ovary, lung, thymus, heart and skeletal muscle, USP15 localizes to the cytoplasm and the nucleus, contains one DUSP domain and functions as a deubiquitinating enzyme that cleaves ubiquitin residues from both ubiquitinylated proteins and ubiquitin-fused precursors, thereby saving these proteins from proteasomal degradation. Via its DUSP domain, USP15 plays a role in the regμlation of the COP9 signalosome (CSN) complex. Three isoforms exist for USP15 due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4, USP15, KIAA0529

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human USP15.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: USP15 polyclonal antibody detects endogenous levels of USP15 protein.

Molecular Weight: ~ 120 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y4E8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only