USP6NL Polyclonal Antibody
Catalogue Numbers: BS61476-50, BS61476-100
Sizes: 50µl, 100µl
Alternative Name: USP6 N-terminal-like protein; Related to the N-terminus of tre; RN-tre; USP6NL; KIAA0019
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q92738
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: GTPase-activating proteins(GAPs) accelerate the intrinsicrate of GTP hydroysis of Ras-related proteins, resulting in downregulation of their active form.RN-tre (related to the N-terminus of tre), also known as USP6NL(USP6 Nterminal like) or TRE2NL, is an 828 amino acid protein thatcontains one RabGAP TBC domain. Expressed in awide variety of tissues, RN-tre functions as a GTPase-activating protein for Rab 5A and isthought to be involved in receptor trafficking, aswell asin the inhibition of EGFR internalization. In response to DNA damage, RN-tre may be phosphorylated by ATM or ATR. The gene encoding RN-tre mapsto human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: USP6NL polyclonal antibody detects endogenous levels of USP6NL protein.
Bioworld Molecular Weight: ~ 86 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of USP6NL polyclonal antibody at 1:500 dilution
Lane 1: Jurkat whole cell lysate(40ug)
Lane 2: PC12 whole cell lysate(40ug)
Lane 3: RAW264.7 whole cell lysate(40ug)
Immunogen: Synthetic peptide, corresponding to amino acids 446-491 of Human USP6NL.
Conjugate: Unconjugated
Modification: Unmodified