Product Description

VASP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91423-50, BS91423-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P50552(Human)

Host: Rabbit

Reactivity: Human

Applications: WB IP

All Applications: WB:1:1,000-1:2,000

Background: The Wiskott-Aldrich syndrome (WAS) is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity, and a propensity for lymphoproliferative diseases. The syndrome is the result of a mutation in the gene encoding a proline-rich protein termed WASP. WASP has been identified as a downstream effector of Cdc42 and has been implicated in Actin polymer-ization and cytoskeletal organization. A distantly related protein, VASP (vaso-dilator-stimulated phosphoprotein), is involved in the maintenance of cytoarchitecture by interacting with Actin-like filaments. VASP shares a limited degree of homology with the amino-terminus of WASP, which is frequently mutated in WAS patients. An established substrate of cAMP and cGMP de-pendent kinases, VASP is phosphorylated on a regulatory Serine residue 157 and localizes to focal adhesions, microfilaments and highly active regions of the plasma membrane. VASP is highly expressed in human platelets and, like WASP, may play a role in cytoskeletal organization.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of VASP on differentLysates using anti-VASP antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: MCF-7 Lane 3: HT29

Bioworld Molecular Weight: 46 kDa

Specificity: VASP polyclonal antibody detects endogenous levels of VASP protein.

Alternative Name: VASP, Vasodilator stimulated phosphoprotein, Vasodilator-stimulated phosphoprotein, VASP, VASP,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified