Vav (phospho Tyr174) rabbit pAb - ES7485

Vav (phospho Tyr174) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7485-50, ES7485-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],

Alternate Name: VAV1; VAV; Proto-oncogene vav

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Vav (phospho Tyr174)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100kD

Human Gene ID: 7409

Human SWISS Prot NO: P15498

Subcellular Location: intracellular, cytosol, plasma membrane, cell-cell junction,

Research Use Only