Product Description

VCP (A346) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3773-50, BS3773-100

Sizes: 50µl, 100µl

Swiss-Prot: P55072

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: VCP (A346) polyclonal antibody detects endogenous levels of VCP protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of VCP (A346) polyclonal antibody in extracts from Hela cells and Raw264.7 cells treated with LPS., Immunohistochemistry (IHC) analyzes of VCP (A346) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 88 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: 15S Mg (2+) ATPase p97 subunit; ATPase p97; IBMPFD; MGC131997; MGC148092; MGC8560; TER ATPase; TERA; p97; transitional endoplasmic reticulum ATPase; valosin-containing protein; yeast Cdc48p homolog

Immunogen: Synthetic peptide, corresponding to amino acids 320-370 of Human VCP.

Conjugate: Unconjugated

Modification: Unmodified