Product Description

VDR (K45) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3756-50, BS3756-100

Sizes: 50µl, 100µl

Swiss-Prot: P11473

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: VDR (K45) polyclonal antibody detects endogenous levels of VDR protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of VDR (K45) polyclonal antibody pAb at 1:500 dilution
Lane 1: Hela whole cell lysate (30ug)
Lane 2: HepG2 whole cell lysate (30ug)
Lane 3: DLD whole cell lysate (30ug)
Lane 4: NIH-3T3 whole cell lysate (50ug)
Lane 5: H9C2 whole cell lysate (30ug)
Lane 6: PC12 whole cell lysate (30ug), Immunohistochemistry (IHC) analyzes of VDR (K45) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 48 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Vitamin D3 receptor; VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1

Immunogen: Synthetic peptide, corresponding to amino acids 11-60 of Human VDR.

Conjugate: Unconjugated

Modification: Unmodified