Product Description

VEGFR2/Flk-1 (I1220) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5541-50, BS5541-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobμlinlike sequences in their extracellμlar domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascμlar endothelial growth factors (VEGFs). On the basis of structural similarity to Flt and Flk-1, it has been specμlated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Flk - 1 / KDR / VEGFR2, VEGFR-2, EC 2.7.10.1, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen, VEGFR2, 16542, Kdr, 6130401C07, Flk-1, Flk1, Krd-1, Ly73, VEGFR-2, VEGFR2, 3791, KDR, 191306, P35968,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: VEGFR2 (I1220) polyclonal antibody detects endogenous levels of VEGFR2 protein.

Molecular Weight: ~ 150, 210 kDa

Pathway: Tumor Angiogenesis, ErbB HER Signaling, ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35968

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only