Versican Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91438-50, BS91438-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P13611(Human) Q62059(Mouse)
Host: Rabbit
Reactivity: Human, Mouse
Applications: IHC WB,
All Applications: IHC:1:50-1:200
WB:1:500
Background: Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a lectin-like sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycosaminoglycan chains. Accumulation around smooth muscle cells in lesions of atherosclerosis, suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels. The human verisican gene maps to chromosome 5q14.3.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Versican polyclonal antibody detects endogenous levels of Versican protein.
Bioworld Molecular Weight: 373/265/182/74 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Versican antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Versican antibody. Counter stained with hematoxylin.
Alternative Name: Chondroitin sulfate proteoglycan 2, GHAP, VCAN, CSPG2, Chondroitin sulfate proteoglycan 2, Chondroitin sulfate proteoglycan core protein 2, Chondroitin sulfate proteoglycan core protein, cartilage, CSPG2, CSPG2, ERVR, GHAP, Glial hyaluronate binding protein, Glial hyaluronate-binding protein, Large fibroblast proteoglycan, PG-M, PGM, VCAN, Versican, Versican core protein, Versican proteoglycan, WGN 1, WGN, WGN1,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified